| |
| author |
Paxtan Perry
| | title |
The Synthesis and Analysis of Triosmium Carbonyl Clusters with Potential Biological Activity
| | abstract |
Several triosmium carbonyl clusters demonstrate biological activity in published
literature. These various complexes possess labile ligands, which have been shown to be
responsible for potential biological activity. The biological reactivity of triosmium decacarbonyl
bisethoxide, (bisethoxide, (Os3(CO)10(µ-OEt)2), and synthetic derivatives are not yet known, but
are predicted to be similar to other biologically active triosmium complexes based on their
similarity in chemical reactivity and structure. In this research, the complexes Os3(CO)8(µ-OEt)2(NCMe)2 and
Os3(CO)9(µ-OEt)2(NCMe) have been synthesized where acetonitrile is a
labile ligand. Reaction progress was monitored through Infrared Spectroscopy (IR) and Thin
Layer Chromatography (TLC); while IR, TLC, and Proton Nuclear Magnetic Resonance
spectroscopy (1H NMR) were used for product confirmation. IR and 1H NMR analysis deduced
the complex Os3(CO)9(µ-OEt)2(NCMe) is formed at room temperature, while it is proposed
through IR analysis that Os3(CO)8(µ-OEt)2(NCMe)2 is formed at high temperatures. In order to
be biologically active, osmium carbonyl complexes must be soluble in polar solvents,
particularly water, so compounds synthesized in this project were tested for solubility in
acetonitrile, ethanol, and water. Os3(CO)10(µ-OEt)2 was found to be soluble in ethanol and not
easily soluble in acetonitrile and water. Future evaluation of the solubility of Os3(CO)9(µ-OEt)2(NCMe) is needed, as the complex decomposed within 36 hours of production (confirmed
by 1H NMR). The final chapter serves as a review of synthetic approaches to synthesize
Os3(CO)10(µ-OEt)2.
| | school |
The College of Liberal Arts, Drew University
| | degree |
B.S. (2022)
|
| advisor |
Mary-Ann Pearsall
|
| committee |
Adam Cassano
Jim Supplee
|
| full text | PPerry.pdf |
| |
