| |
| author |
Kayla Witkowski
| | title |
Exploring neuroprotective effect of a combined strategy of LM11A-31, Resveratrol, and
Methylene Blue as a treatment for Alzheimer's Disease pathology: A pilot study
| | abstract |
Alzheimer's Disease (AD) is the most common form of dementia and neurodegenerative
disorder the leads to cognitive impairment such as severe memory loss. AD is rapidly increasing
amongst the human population with no treatment available. There are many drugs currently
being looked at, but none are able to treat to the sporadic form of the disease. AD patients
experience brain dystrophy thought to be induced by molecular hallmarks of the disease such as
Aβ accumulation, hyperphosphorylated tau, oxidative stress and neuroinflammation. Some drugs
that are being looked at as possible treatments for AD are LM11A-31, Resveratrol, Methylene
Blue. Each of these drugs are thought to exhibit neuroprotective effects but is unclear how they
promote cell survivability in AD models and if this neuroprotective effect is transferable from rat
models to human patients. Also, the neuroprotective effect demonstrated in past studies is fairly
limited. As LM11A-31, Resveratrol, and Methylene Blue are believed to modulate similar
molecular pathways attributed causing neuronal dystrophy in AD patients, I present a pilot study
looking at if a combined treatment strategy of all three drugs will increase neuroprotection
against a common neurotoxin when used in excess, NMDA, in an in vitro model system.
Neuronal cultures were stressed with individual compounds and combined treatments of NMDA,
LM11A-31, Resveratrol, and Methylene Blue. I report LM11A-31, Resveratrol, and Methylene
Blue did not offer strong neuroprotective properties against NMDA individually or in two
combinations of the drugs. Limited neurotoxicity was also reported when treating cells with
either FAB or NMDA.
| | school |
The College of Liberal Arts, Drew University
| | degree |
B.S. (2021)
|
| advisor |
Roger Knowles
|
| committee |
Graham Cousens
Kim Choquette
|
| full text | KWitkowski.pdf |
| |
