Drew University Library : University Archives : Theses and Dissertations
    
author Shady Barsoom
title The potential synergistic effects of DCP-LA and resveratrol in mitigating cytotoxicity in an oxidative stress model of Alzheimer's disease
abstract Alzheimer's disease (AD) is one of the most common neurodegenerative disorders whose prevalence is increasing each year. Alzheimer's is characterized by a progressive decline in memory, cognition, and motor activities. The two hallmark pathophysiological symptoms of AD are the formation of toxic amyloid beta (Aβ) plaques and neurofibrillary tangles (NFT's). As a result, several treatments and trials have been conducted to minimize or remove the presence of these harmful plaques and tangles, but success has been limited. A protein kinase C epsilon (PKCε) activator known as DCP-LA has been used to stimulate neurologically beneficial processes such as neurite outgrowth and synaptogenesis. In addition, through its interaction with PKCε, DCP-LA may help to reduce the amount of hyperphosphorylated tau that results in NFT's.

Resveratrol, a compound found in red wine and several foods, may also be beneficial in mitigating some of the neurodegenerative processes seen in AD by stimulating the activation of ADAM10, a metalloproteinase that may result in the decrease of harmful oligomeric Aβ plaques. While several studies have been conducted on the potential beneficial effects of DCP-LA and resveratrol independently, their effects when used in combination have not been fully characterized. Thus, I propose a hypothetical set of experiments that would seek to identify the possible synergistic or complementary effects of DCP-LA and resveratrol in mitigating the cellular symptoms of cytotoxicity in an FAB model of Alzheimer's disease. The use of DCP-LA and resveratrol in combination with each other may result in a more pronounced beneficial cellular response to cytotoxicity.

school The College of Liberal Arts, Drew University
degree B.A. (2022)
advisor Roger Knowles
full textSBarsoom.pdf